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HERDIN Record #: PCHRD080407020831 Submitted: 05 August 2007

A cross-sectional study of the prevalence of intensity of infection with Schistosoma japonicum in 50 irrigated and rain-fed villages in Samar Province, the Philippines .

Remigio Olveda,
Portia Alday,
Patrick Belisle,
Mushfiqur R. Tarafder,
Steven Riley,
Lawrence Joseph,
Helene Carabin,
 S. McGarvey,
Ryan O Gonzales,
Ernesto Jr Balolong

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BACKGROUND: Few studies have described heterogeneity in Schistosoma japonicum infection intensity, and none were done in Philippines. The purpose of this report is to describe the village-to-village variation in the prevalence of two levels of infection intensity across 50 villages of Samar Province, the Philippines.

METHODS: This cross-sectional study was conducted in 25 rain-fed and 25 irrigated villages endemic for S. japonicum between August 2003 and November 2004. Villages were selected based on irrigation and farming criteria. A maximum of 35 eligible households were selected per village. Each participant was asked to provide stool samples on three consecutive days. All those who provided at least one stool sample were included in the analysis. A Bayesian three category outcome hierarchical cumulative logit regression model with adjustment for age, sex, occupation and measurement error of the Kato-Katz technique was used for analysis.

RESULTS: A total of 1427 households and 6917 individuals agreed to participate in the study. A total of 5624 (81.3 percent) participants provided at least one stool sample. The prevalences of those lightly and at least moderately infected varied from 0 percent (95 percent Bayesian credible interval (BCI): 0 percent-3.1 percent) to 45.2 percent (95 percent BCI: 36.5 percent-53.9 percent) and 0 percent to 23.0 percent (95 percent BCI: 16.4 percent-31.2 percent) from village-to-village, respectively. Using the 0-7 year old group as a reference category, the highest odds ratio (OR) among males and females were that of being aged 17-40-year old (OR = 8.76; 95 percent BCI: 6.03-12.47) and 11-16-year old (OR = 8.59; 95 percent BCI: 4.74-14.28), respectively. People who did not work on a rice farm had a lower prevalence of infection than those working full time on a rice farm. The OR for irrigated villages compared to rain-fed villages was 1.41 (95 percent BCI: 0.50-3.21).

DISCUSSION: We found very important village-to-village variation in prevalence of infection intensity. This variation is probably due to village-level variables other than that explained by a crude classification of villages into the irrigated and non-irrigated categories. We are planning to capture this spatial heterogeneity by updating our initial transmission dynamics model with the data reported here combined with 1-year post-treatment follow-up of study participants. (Author)

Publication Type
Journal
Publication Sub Type
Others
Title
Bio Med Central Public Health
Frequency
Unknown
Publication Date
March 2006
Volume
9
Issue
6
Page(s)
61
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Abstract Print Format

Citation

1. Asian Schistosomiasis: Current status and prospects for control leading to elimination.
2. Modeling Schistosoma japonicum infection under pure specification bias: Impact of environmental drivers of infection.
3. Population genetics of Schistosoma japonicum within the Philippines suggest high levels of transmission between humans and dogs.
 

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