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HERDIN Record #: PCHRD020708110244 Submitted: 08 February 2008

Primary cutaneous CD30+ anaplastic large cell lymphoma: Report of a rare case.

Daisy King-Ismael,
Melanie Pauline G. Chao-Lo,

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Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare type of non-Hodgkin's lymphoma comprising approximately 0.9-3.0% of all cutaneous lymphomas.3-14'15 No case has yet been reported locally. PCALCL is characterized by the absence of systemic involvement, spontaneous regression and low recurrence rate especially in localized lesions.

We present a 47-year-old female with a 1 Vi-years history of two asymptomatic erythematous indurated plaques on the right arm. Skin punch biopsy revealed dense infiltrates of non-epidermotropic, large, irregularly-shaped lymphocytes with hyperchromatic and pyknotic nuclei. Immunohistochemistry revealed that these atypical cells are anaplastic lymphoma kinase (ALK) positive, CD30+, CD3-, CD20- and epithelial membrane antigen (EMA) negative. Clinical, histopathological and immunohistochemical findings are consistent with PCALCL. Work-ups revealed no systemic involvement. Short course CHOP (Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) chemotherapy resulted in total resolution of skin lesions; however, recurrence was noted 12 months after treatment. She then underwent radiotherapy and achieved complete remission. (Author)

Publication Type
Journal
Publication Sub Type
Case report
Title
Journal of the Philippine Dermatological Society
Frequency
Semi-Annual
Publication Date
May 2007
Volume
16
Issue
1
Page(s)
49-51
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Abstract Print Format
 

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